San Francisco 49ers rookie running back Isaac Guerendo (foot, hamstring) was limited in practice for the second straight day this week on Friday. Guerendo, who did not play in the Week 16 loss to the Miami Dolphins,

RB Jordan Mason filled in admirably to start the year, but he was hit with a shoulder injury in Week 6 that he battled until McCaffrey’s return in Week 10. McCaffrey and Mason were both hurt in a Week 13 loss to the Buffalo Bills, which pushed rookie fourth-round pick RB Isaac Guerendo into the starting role.

Curious to know about 49ers RB Isaac Guerendo‘s injury? The standout rookie has drawn attention for his breakout performances on the field and his determination to play despite a recent foot injury. From his impressive debut to becoming a key player in the 49ers’ backfield,

The San Francisco 49ers have been decimated by injuries all year, specifically at the running back position. Christian McCaffrey and Jordan Mason are both on injured reserve, leaving rookie Isaac Guerendo as the top back.

San Francisco 49ers running back Isaac Guerendo appeared on Wednesday's injury report due to a hamstring issue sustained during last week's game against

Well this isn't good. 49ers rookie Isaac Guerendo is nursing a new injury. Kyle Shanahan revealed Guerendo was held out of Wednesday's practice with a hamstrin

In a long line of 49ers injuries, neither Trent Williams or Isaac Guerendo will suit up against the Dolphins in Week 16.