For about 30 minutes on Saturday afternoon, it looked like the Virginia Tech Hokies were about to win their second game in a row and move to 3-2 in ACC play. Unfortunately, a lopsided third quarter changed everything, and the No. 16 Louisville Cardinals (7-1, 4-1) came from behind to defeat the Hokies 28-16 (3-6, 2-3).

Isaac Brown rushed for 130 yards and a touchdown before leaving late with a leg injury and Keyjuan Brown scored twice in the second half to lift No. 16 Louisville to a 28-16 victory over Virginia Tech.

The Hokies fired their fourth-season head coach, Brent Pry, last month, after a poor 0-3 start to the year. Philip Montgomery replaced him as the interim head coach, and the program is in search of its next head coach.

View news about the Louisville Cardinals vs. Virginia Tech Hokies football game played on November 01, 2025 including player news, injury news, predictions, analysis and more.

Who will miss the Louisville Cardinals' Week 10 ACC college football game vs. Virginia Tech? Here's the latest Louisville football injury report.

While the Hokies enter their second open date, their fans remain obsessed with the program’s coaching search and incessant chatter that recently deposed Penn State coach James Franklin could be

The Hokies look to win against a ranked opponent for the first time since 2021 with No. 16 Louisville coming to Blacksburg.

Nick Saban revealed on College GameDay on Saturday from Salt Lake City, Utah, that he's a "player," not a coach anymore.