The FDA Modernization Act 2.0 has shifted from animal testing to New Approach Methodologies (NAMs) for preclinical drug development. Three-dimensional (3D) bioprinting has emerged as a premier NAM, ...

Researchers at Helmholtz Munich and the Technical University of Munich (TUM) have developed Nicheformer, the first large-scale foundation model that integrates single-cell analysis with spatial ...

As a researcher, I still remember the discomfort I felt every time I had to sacrifice laboratory animals for an experiment. For decades, animals like mice, rats and pigs have been essential tools in ...

A fundamental challenge in preclinical research is accurately predicting human responses using conventional animal models. Traditional approaches often fail to adequately model human disease, creating ...

The team observed the emergence of the three-dimensional embryo-like structures under a microscope in the lab. These started producing blood (seen here in red) after around two weeks of development - ...

How do biological cells join forces to form a structure? In her Ph.D. research, Daphne Nesenberend uses mathematics to show how forces and cooperation between cells create structure—and how ...

Testicular organoids that support spermatogenesis and generate functional haploid germ cells are still lacking. Here, we developed a formation-differentiation culture approach to generate optimized ...