The DNA damage-activated protein kinase Chk1 is known to undergo auto-phosphorylation, however the sites and functional significance of this modification remain ...

Protein kinases orchestrate progression through the cell cycle by reversible phosphorylation of substrates that control DNA replication, mitotic entry, spindle assembly, and cytokinesis.

A study published in Cell Research advances a central idea in stem cell biology by identifying a checkpoint that controls the identity of many different types of stem cells across developmental stages ...