Helicases are enzymes that unwind DNA and RNA. They’re central to cellular life, implicated in a number of cancers and infections—and, alas, extraordinarily difficult to target with drugs. Now, new ...

Helicases are specialised motor proteins that harness the energy of ATP hydrolysis to unwind and translocate along nucleic acid duplexes, thereby facilitating critical processes such as DNA ...

For patients with cancers harboring certain genetic defects, the first-in-class targeted therapy RO7589831, which targets the DNA repair enzyme Werner helicase, demonstrated early signals of efficacy ...

SARS-CoV-2 helicase (nsp13) is an essential motor enzyme that unwinds double-stranded RNA during viral replication by coupling ATP hydrolysis to mechanical translocation. As a core component of the ...

RNA helicases are a group of enzymes that bind to and alter RNA in an ATP-dependent way. They play significant roles in RNA metabolism, gene expression regulation, and innate immunity. Different RNA ...

Helicases are enzymes that unwind DNA and RNA. They're central to cellular life, implicated in a number of cancers and infections - and, alas, extraordinarily difficult to target with drugs. Now, new ...

DNA repair mechanism: HELQ helicase remodels stalled replication forks into stable structures, preventing harmful mutations under replication stress. Advanced imaging tool: RF-SIRF maps reversed forks ...

For the first time, scientists have witnessed the very moment DNA begins to unravel, revealing a necessary molecular event for DNA to be the molecule that codes all life. A new study from King ...

Since the 1990s, nanopores have been used for sequencing strands of DNA. A voltage is applied across the nanopore, which is embedded in a thin lipid membrane, causing a stretch of DNA to thread ...

Enzymes, which are crucial to controlling how cells replicate in the human body, could be the very ingredient that encourages DNA to spontaneously mutate -- causing potentially permanent genetic ...

A new study from molecular biologists at Indiana University has identified cellular processes that appear to supercharge both the growth and shrinkage of the chemical "caps" on chromosomes associated ...