Both novel bifunctional (SON-1411) and monofunctional (SON-1400) fusion proteins exhibit wild-type binding to the IL-18 receptor (IL-18Rc), coupled with undetectable binding to the inhibitory IL-18 ...
PRINCETON, N.J., June 13, 2024 (GLOBE NEWSWIRE) -- Sonnet BioTherapeutics Holdings, Inc. (SONN) (the "Company" or "Sonnet"), a clinical-stage company developing targeted immunotherapeutic drugs, ...
11monon MSN
Researchers discover short form of a tumor-produced protein activates natural killer cells
A group of scientists in China has revealed a novel mechanism whereby a short form of IL-18, generated by caspase-3 cleavage ...
Interleukin-18 (IL-18) is a pro-inflammatory cytokine that modulates innate and adaptive immune responses. Decoy-resistant IL-18, DR-18, from Simcha Therapeutics Inc., is an engineered IL-18 cytokine ...
Interleukins (ILs), a group of cytokines, are produced by leukocytes and non-immune cells like endothelial, fibroblasts, smooth muscle, epithelial and bone marrow cells. 1 ILs mainly act as ...
Saleela M. Ruwanpura, Louise McLeod, Lovisa F. Dousha, Huei J. Seow, Alison C. West, Alice J. West, Teresa Weng, Mohammad Alanazi, Martin MacDonald, Paul T. King ...
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