Communication between osteoblasts and endothelial cells (ECs) is essential for bone turnover, but the molecular mechanisms of such communication are not well defined. Here we identify Cxcl9 as an ...

Osteoblasts are the cells required for bone synthesis and mineralization, both during the initial formation of bone and during bone remodelling. These cells are present on the bone surface in the form ...

Patients with advanced prostate cancer frequently develop bone metastases. The tropism of prostate cancer cells for bone and their tendency to induce the osteoblastic phenotype is a result of ...

Estrogen plays an important role in keeping bones healthy. Now, researchers investigated how membrane-initiated estrogen receptor alpha (mERα) signaling in specific cell types of female mice affects ...

Panel A shows osteoclasts and osteoblasts in normal bone (toluidine blue, ×100). The large osteoclast is actively resorbing bone. Osteoblasts are small, cuboid cells that actively lay down bone matrix ...

Osteoporosis, a major worldwide health problem, affects 4 million to 6 million women and 1 million to 2 million men in the United States. Even more people have decreased bone mass, which, in addition ...