To overcome these limitations, the research team developed a "targeted RNA acetylation system (dCas13-eNAT10)" by combining Cas13, gene scissors that precisely target desired RNA, with a hyperactive ...

Cells contain a blueprint in the form of DNA that dictates what they can make. This blueprint is converted into a message (mRNA), which is then converted into a protein. Although DNA remains the same ...

A Northwestern Medicine study published in the Journal of Clinical Investigation has uncovered a connection between a well-known cancer-related protein and a major RNA modification process, which may ...

RNA modifications are chemical marks on RNA molecules that can influence RNA stability, processing and function. Although several of these marks have been linked to spermatogenesis and male fertility, ...

Scientists at the UCLA Health Jonsson Comprehensive Cancer Center and the University of Toronto have revealed how a tiny chemical modification in RNA, known as m 6 A, plays a critical role in the ...

RNA plays critical roles in nearly all biological processes, but current methods for sequencing RNA are significantly limited. This is partially because RNA molecules are chemically modified within ...

A new tool called SigRM helps researchers study RNA modifications in individual cells, improving our understanding of how genes are regulated. Researchers have developed a new tool that will help ...

Nonalcoholic fatty liver disease (NAFLD) is a prevalent metabolic disorder with a complex pathogenesis. Although epitranscriptomic modifications such as N6-methyladenosine (m6A) have been implicated ...

A new perspective on gut immunity is highlighting the powerful role of RNA modifications in shaping how the body maintains balance in the digestive system. At the center of this emerging view are ...

如果说DNA是人类细胞中的“总说明书”，那么RNA则可被视作一份“工作副本”，帮助细胞利用遗传信息生成蛋白质，并执行维持生命活动所需的重要过程。 RNA在生成和加工过程中会发生化学修饰。这些修饰如同工作副本上的小标记，虽不会改变DNA中原有的遗传指令，却能影响RNA如何被加工、使用，以及它在细胞中保持稳定的时间。RNA修饰参与细胞发育、环境响应以及细胞状态转换等过程，也与癌症、神经系统疾病等疾病有 ...