New research led by the University of Minnesota Medical School demonstrates that molecules acting as "molecular bumpers" and "molecular glues" can rewire G protein-coupled receptor (GPCR) signaling, ...

A bitter taste receptor, TAS2R14, has been shown to respond to both extracellular and intracellular signals. Indeed, it can respond to both signals simultaneously. This finding is especially ...

Our biological processes rely on a system of communications — cellular signals — that set off chain reactions in and between target cells to produce a response. The first step in these often complex ...

University of Oregon researchers have identified protein interactions that regulate the response of cells to steroid hormones. The discovery, they say, could lead to new ways to boost the ...

Partial opioid agonists have mixed or limited action when they bind to your opioid receptors. So, doctors often use them to treat opioid use disorder. Protein receptor sites are like keyholes on the ...

Relationship of STAT3-mediated treatment resistance on activated MAPK signaling in pancreatic cancer. Background: Metastatic tumors may be fundamentally different than the primary tumor. This ...

Allosteric modulation provides exciting opportunities for drug discovery of enzymes, ion channels, and G protein-coupled receptors. As cation channels gated by extracellular ATP, P2X receptors have ...

Checkpoint inhibitors are antibody-based cancer therapies that unlock the immune system’s natural ability to fight cancer. These treatments work by blocking special proteins called immune checkpoints, ...