Building on well-established observations that SirT1 levels and activity are reduced during states of overnutrition, we recreated these SirT1 reductions in nonobese animals. We find that reducing ...

Liver x receptors (LXRs) are hypothesized to serve as a link between lipid metabolism and inflammation by promoting cholesterol efflux as well as exhibiting anti-inflammatory properties. NAD-dependent ...

SIRT1 represents a mechanistically validated target with notable progress in early-stage drug development for MASLD. With further in-depth analysis of its regulatory network and continued optimization ...

Feeding and fasting cycles exert control over metabolism and energy utilization of organisms. Any aberration is known to cause metabolic diseases, liver dysfunctions and accelerated aging. Expression ...

Matthew P. Gillum; Maya E. Kotas; Derek M. Erion; Romy Kursawe; Paula Chatterjee; Kevin T. Nead; Eric S. Muise; Jennifer J. Hsiao; David W. Frederick; Shin Yonemitsu ...