A new review argues that glioblastoma evades EGFR-targeted therapies through compensatory STAT3 activation, positioning the ...
A new editorial perspective was published in Oncotarget, titled "STAT3 as a biologically relevant target in H3K27M-mutant diffuse midline glioma." Pediatric H3K27M-mutant diffuse midline gliomas (DMGs ...
Significance of MYC rearrangement and chemotherapy type on survival outcomes of patients with central nervous system lymphoma.
Effect of IMiD compounds on CD38 expression on multiple myeloma cells: MOR202, a human CD38 antibody in combination with pomalidomide. This is an ASCO Meeting Abstract from the 2015 ASCO Annual ...
Schematic diagram of the IL-6/JAK/STAT3 signaling pathway activation in mouse liver macrophages. IRs, inhibitory receptors (IRs); ICIs, immune checkpoint inhibitors; IL-6, interleukin-6; ALT, alanine ...
Hepatitis B virus (HBV) infection is a major risk factor for cirrhosis and liver cancer, and its treatment continues to be difficult. We previously demonstrated that a dopamine analog inhibited the ...
Raajit Rampal, MD, describes the JAK-STAT pathway and how it’s fundamental to all types of myelofibrosis. As Aaron pointed out, we see different manifestations. We see patients who have a more ...
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