NFL Week 10 Odds & Picks
Digest more
The 2025-26 NFL regular season is nearly at the midway point, and Week 8 has been one for favorites, as teams that were favored have gone 10-2 against the spread so far. Nine of the 12 games have gone over the total, with one game falling under and two pushes.
Vaughn Dalzell breaks down whether or not Jonathan Taylor is good bet to become the first running back to win MVP since 2012.
College football Week 10 betting spreads, lines, point totals for every game on Big 12 schedule, with odds for favorites, underdogs in each matchup.
The over/under, which opened at 47.5 total points, has risen to 48.5, and the moneyline has held steady at Giants +130, 49ers -155. The Giants have been underdogs in all eight of their previous games this year.
Mike Florio and Chris Simms explore if the 49ers can bounce back in Week 9 against the Giants, who could make this a close one.