Using the polyamine toxin philanthotoxin, which selectively blocks calcium-permeable AMPA receptors, we show that synaptic transmission onto single hippocampal interneurons occurs by afferent-specific ...

Philosophical Transactions: Biological Sciences, Vol. 369, No. 1633, Synaptic plasticity in health and disease (5 January 2014), pp. 1-7 (7 pages) The prevailing view at present is that postsynaptic ...

Information processing in the brain is thought to exploit not only classical homosynaptic connections between pre- and postsynaptic neurons but also heterosynaptic interactions between separate ...

BALTIMORE--(BUSINESS WIRE)--Cerecor Inc. (NASDAQ: CERC), a clinical-stage biopharmaceutical company developing treatments to make a difference in the lives of patients with neurological and ...

Glutamate, the major excitatory neurotransmitter in the brain, acts primarily on two types of ionotropic receptors: α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors and N-methyl-D ...

One of the earliest signs of amyloid-β (Aβ) toxicity is synaptic loss, and recent work from a number of labs has shown that Aβ causes depressed synaptic transmission due to removal of cell surface ...

Behind every successful neuron, and some unsuccessful ones, there are astrocytes. These accessory cells nurture and protect their finicky neighbors by providing nutrients, neurotrophic factors, and ...

Even though psychiatric disorders such as schizophrenia, bipolar disorder, and autism spectrum disorder (ASD) are quite common, their diagnosis and treatment are challenging. While doctors today have ...

While the COVID pandemic has thankfully been over for some time now, there is still a considerable number of people in the world (about 400 million) suffering from long COVID. Long COVID is a chronic ...