Background Belimumab and low dose IL2 (Ld-IL2) has been identified effective in the treatment of systemic lupus erythematosus (SLE). However, the application of combined therapy for SLE has not been ...

Objective This study aims to evaluate the role of antiphospholipid antibodies (aPLs) in patients with SLE with heart valve ...

Purpose to identify the presence of variants in gene related to monogenic lupus and their relationship with clinical manifestations in childhood-onset systemic lupus erythematosus (cSLE) or lupus-like ...

Background Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a strong genetic component (Block, Winfield et al. 1975, Deapen, Escalante et al. 1992, Alarcon- Segovia, ...

Purpose Tertiary lymphoid structures (TLS) are organized aggregation of immune cells at sites of inflammation. The development of TLS in autoimmune settings indicate that they may be sites for both ...

Objective BAFF and APRIL signal through TACI, BCMA, and/or BAFF-R, and play important roles in the activation, differentiation, and/or survival of B cells, particularly antibody-secreting cells, as ...

Purpose TLR7 and TLR8 (TLR7/8) are members of the Toll-Like Receptor family that recognize single strand RNA. Activation of TLR7/8 within immune cells elevates pro-inflammatory cytokines and type ...

Objective The objective of this review is to highlight the role of Neutrophil Extracellular Traps (NETs) in the pathogenesis of Systemic Lupus Erythematosus (SLE), focusing on their development, ...

Objective To evaluate the clinical utility of the multianalyte assay panel (MAP), commercially known as AVISE Lupus test (Exagen Inc.), in patients suspected of SLE. Methods A systematic review of ...

Background Systemic lupus erythematosus (SLE) is a chronic, complex autoimmune disease characterized by pathogenic autoantibodies and tissue damage to multiple organ systems. Nipocalimab is a novel ...

Objectives This study aimed to investigate hemostatic variables in pregnant patients with Systemic Lupus Erythematosus (SLE) in relation to preeclampsia (PE), antiphospholipid antibody (aPL) status ...

Background Systemic Lupus Erythematosus (SLE) is a prototypic, systemic autoimmune disease that can affect many organs. Current treatment of SLE is largely empirical, while the existing ...