The body has an intricate system to defend against infections where each type of immune cell plays a distinct role. Now, a ...

Immunologists from the Institute have been the first to uncover a role for a family of RNA binding proteins in the function ...

Special T cells known as ‘CD8+ T cells’ are responsible for directly identifying and targeting infected cells. In the context of cancer, these cells lose their function and allow tumors to progress.

A Northwestern Medicine study has uncovered new insights that may aid in understanding and potentially treating one of the most common and aggressive forms of non-Hodgkin lymphoma, according to ...

Transcription factor T-bet regulates memory B cell subsetsT-bet expression is required for persistence of memory B cells that have rapid differentiation potential to become antibody-producing plasma ...

Dysfunctional mitochondria are a hallmark of T cell ageing and contribute to organismal ageing. This arises from the accumulation of reactive oxygen species (ROS), impaired mitoch ...

A “complete eradication” of B cells with chimeric antigen receptor T-cell therapy is responsible for the long-term, drug-free remission from autoimmune diseases observed after treatment ...

Sickle cell disease changes CD8+ T-cell chromatin structure, affecting cancer immunotherapy response.

Capstan Therapeutics scientists demonstrate that lipid nanoparticles can engineer CAR T cells within the body without laboratory cell manufacturing and ex vivo expansion.