Scientists have mapped the molecular structure of glutamate receptors in the cerebellum for the first time using cryo-electron microscopy.

Mature AMPA-receptor-containing synapses stabilize the branches on which the synapses are located. Stabilized branches can then support the addition of new branches.

Brain Receptor Structure Revealed to Support Cerebellum Function Repair June 23, 2025 Neurons [BlackJack3D / 1495440392 / E+] ...

The N-methyl-D-aspartate (NMDA) receptor contributes to synaptic plasticity in the central nervous system and is both serine-threonine and tyrosine phosphorylated. In CA1 pyramidal neurons of the ...

The UAB researchers showed that TREM2 — which stands for triggering receptors expressed on myeloid cells 2 — is predominantly ...

This useful study presents a biologically realistic, large-scale cortical model of the rat's non-barrel somatosensory cortex, investigating synaptic plasticity of excitatory connections under varying ...

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May 7, 2025 — Researchers have discovered distinct roles for two dopamine receptors located on nerve cells within the portion of the brain that controls approach ...

In macaque monkeys, blocking NMDA receptors selectively disrupted late onset modulations of neural activity in V1 (i.e., recurrent processing) during figure-ground detection, whereas blocking AMPA ...

After binding to its receptor, located in lipid rafts, by domain 1, the prototoxin is cleaved to the active form (41 kDa) by cell proteases, such as furin, which cleaves a C-terminal 45 amino acid ...

Ligand-gated ion channels undergo conformational changes that transfer the energy of agonist binding to channel opening. Within ionotropic glutamate receptor (iGluR) subunits, this process is ...