Scientists have mapped the molecular structure of glutamate receptors in the cerebellum for the first time using cryo-electron microscopy.

More information: Federico Miguez-Cabello et al, GluA2-containing AMPA receptors form a continuum of Ca 2+ -permeable channels, Nature (2025). DOI: 10.1038/s41586-025-08736-2 ...

As AMPA receptors are one of the most important molecules in neurotransmission, this method could potentially teach us a lot about the mechanisms of psychiatric disorders.

AMPA receptors are critical to the fast transfer of information and memory formation in the brain, such as hearing and remembering a person’s name. The subtype of AMPA receptors in this study, CP-AMPA ...

Thus, when AMPA receptors are not present, synapses that have only NMDA receptors cannot pass along an electric current and are referred to as "silent." Unsilencing synapses ...

AMPA receptors (AMPARs) are widely distributed in the central and peripheral nervous systems. They are mainly located in postsynaptic cells, but can also be found in pre-synaptic sites and glia ...

Reference: “Differential dendritic integration of long-range inputs in association cortex via subcellular changes in synaptic AMPA-to-NMDA receptor ratio” by Mathieu Lafourcade, Marie-Sophie H. van ...

A knockin mouse line was made to label endogenous AMPA receptors, enabling direct observation of synaptic plasticity in behaving animals with single-synapse resolution across the entire brain.

In hippocampal dendrites it coalesced AMPA receptor subunits GluA1-3. All told, this synaptic organizer seemed to do just what the scientists had predicted. What about in vivo? The authors tested the ...

NMDA receptors possess certain unique features that distinguish them from other glutamate receptors, such as α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA).

Postsynaptic AMPA/glutamate receptors, essential for neuronal excitability, are important targets for anticonvulsant therapy. This single channel study of the selective noncompetitive AMPA receptor ...

The location and number of neurotransmitter receptors are dynamically regulated at postsynaptic sites. However, currently available methods for visualizing receptor trafficking require the ...