Israel and Iran have opened a new chapter in their long history of conflict when Israel launched a major attack with strikes early Friday on Tehran.

It follows daytime attacks from both sides, with Israeli strikes in Tehran continuing and Iran firing more missiles towards Israel.

DUBAI, United Arab Emirates (AP) — Israel launched an expanded assault on Iran on Sunday, with direct strikes targeting its energy industry and Defense Ministry headquarters, while Tehran unleashed a fresh barrage of missiles blamed for the deaths of four people and injuries of many others.

Trump warns Iran not to retaliate against U.S. targets in the Middle East while also predicting Israel and Iran would 'soon' make a deal to end their escalating conflict.

Israel targeted Iran’s Defense Ministry headquarters in Tehran and sites it alleged were associated with Iran’s nuclear program, while Iranian missiles evaded Israeli air defenses and slammed into buildings deep inside Israel.

Regime change in Iran could be a result of Israel's military attacks on the country, Israeli Prime Minister Benjamin Netanyahu told Fox News on Sunday, saying Israel would do whatever is necessary to remove the "existential threat" posed by Tehran.

Israel warns "Tehran will burn" if Iran continues firing missiles, while state media say 60 people have been killed in a strike on Iran's capital.

Israel targeted a major airport in the capital used for both military and civilian purposes, while Iran attacked Israel with waves of ballistic missiles.