Thorax

Maternal BMI and smoking partly explain the association between maternal socio-economic position and offspring asthma

Background Numerous studies have found associations between parental socio-economic position (SEP) and offspring asthma.
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Previous tuberculosis disease as a risk factor for chronic obstructive pulmonary disease: a cross-sectional analysis of multicountry, population-based studies

Background Risk factors for COPD in high-income settings are well understood; however, less attention has been paid to contributors of COPD in low-income and middle-income countries (LMICs) such as ...
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Understanding lung disease following extremely preterm birth

Individuals born extremely preterm (EP-born) must complete lung development outside the uterus, affecting the maturation and growth of airways and alveoli. They often show signs of both obstructive ...
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New NICE asthma guideline: evidence-based gold standard approach or unachievable utopia?

The number of asthma deaths among children and young people (CYP) in the UK has remained stubbornly constant despite advances in medication, delivery systems and maintenance and reliever therapy ...
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Glucagon-like peptide-1 receptor agonists may benefit cardiopulmonary outcomes in patients with COPD

4 China Medical University College of Chinese Medicine, Taichung, Taiwan Background Clinical studies have shown that glucagon-like peptide-1 receptor agonists (GLP-1 RA) can have beneficial effects on ...
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Early mortality after surgical resection for lung cancer: an analysis of the English National Lung cancer audit

1 Nottingham Respiratory Research Unit, University of Nottingham, City Hospital, Nottingham, UK 2 Epidemiology and Public Health, University of Nottingham, City Hospital, Nottingham, UK 3 Respiratory ...
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The five-repetition sit-to-stand test as a functional outcome measure in COPD

1 NIHR Respiratory Biomedical Research Unit, Royal Brompton & Harefield NHS Foundation Trust and Imperial College, Harefield, UK 2 Harefield Pulmonary Rehabilitation Unit, Royal Brompton & Harefield ...
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Capsaicin responsiveness and cough in asthma and chronic obstructive pulmonary disease

BACKGROUND Chronic cough is associated with an increased sensitivity to inhaled capsaicin in a number of conditions but there are no data for patients with more severe asthma or chronic obstructive ...
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Pneumonia in low and middle income countries: progress and challenges

1 Department of Paediatrics and Child Health, Red Cross War Memorial Childrens Hospital, University of Cape Town, Cape Town, South Africa 2 National Institute for Communicable Diseases, Division of ...
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Paradoxical reactions during tuberculosis treatment in patients with and without HIV co-infection

1 Department of Thoracic and HIV Medicine, Royal Free Hospital, London, UK 2 Department of Infectious Diseases, Royal Free Hospital, London, UK 3 Department of Primary Care and Population Sciences, ...
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The Clinical COPD Questionnaire: response to pulmonary rehabilitation and minimal clinically important difference

Background The Clinical COPD Questionnaire (CCQ) is a simple 10-item, health-related quality of life questionnaire (HRQoL) with good psychometric properties. However, little data exists regarding the ...
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S90 FRONTIER-3: a randomized, phase 2a study to evaluate the efficacy and safety of tozorakimab (an anti-interleukin-33 monoclonal antibody) in early-onset asthma

2 Research and Early Development, Respiratory and Immunology, BioPharmaceuticals RandD, AstraZeneca, Cambridge, UK 3 Respiratory and Immunology, Biometrics and Statistical Innovation, Late Respiratory ...