Epothilones are 16-membered macrolides that can act as microtubule-targeting agents to tackle cancer. Many synthetic analogues have been investigated for their activity, yet often based on macrolide ...

Optimizing molecules to improve their properties is a fundamental challenge in drug design. For a fine-tuning of molecular properties without losing bio-activity validated in advance, the concept of ...

Although studies in drug discovery have gained momentum in recent years, the conversion of drugs in use today into less toxic derivatives with pharmacologically superior properties is still of great ...

Existing medications i.e. the antipsychotic drugs are known to be effective in treating only the positive symptoms of schizophrenia, while being ineffective on negative and cognitive symptoms of the ...

Chemical structure of trans-resveratrol. Resveratrol is a natural polyphenolic phytochemical found in redwine, grapes, peanuts, and some berries. It is biosynthesized in response to pathogenic attack ...

The novel coronavirus disease, COVID-19, was first identified in the city of Wuhan, China at the end of December 2019. At the onset of the disease a series of pneumonia incidents were reported to ...

1 College of Pharmacy, Dankook University, Cheonan-si, South Korea 2 School of Pharmacy, Jeonbuk National University, Jeonju-si, South Korea A preliminary study to develop a novel synthetic method for ...

Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012 Jinan, Shandong, P.R ...

ABSTRACT: Novel 4-Chloro-2-[(1-phenyl-1H-tetrazol-5-ylimino)-methyl] phenol (Cl-PTMP) and its transition metal complexes were synthesized and characterized by FT-IR, 1H-NMR, UV-Vis spectroscopy, Mass ...

In Eli Lilly and Company v. Teva Parenteral Medicines, Inc., the Federal Circuit affirmed the district court’s decision that Eli Lilly’s patent to pemetrexed is not invalid for obviousness-type double ...