Halicin - Wikipedia
Halicin was identified by artificial intelligence researchers, including bioengineer James Collins, at the MIT Jameel Clinic in 2019 using an in silico deep learning approach, as a likely broad-spectrum antibiotic.
Artificial intelligence yields new antibiotic - MIT News
Feb 20, 2020 · Halicin (top row) prevented the development of antibiotic resistance in E. coli, while ciprofloxacin (bottom row) did not. Using a machine-learning algorithm, MIT researchers have identified a powerful new antibiotic compound.
Safety and efficacy evaluation of halicin as an effective drug for ...
May 8, 2024 · Halicin, the first antibacterial agent discovered by artificial intelligence, exerts broad-spectrum antibacterial effects and has a unique structure. Our study found that halicin had a good inhibitory effect on clinical isolates of drug …
Assessment of the Antibacterial Efficacy of Halicin against …
This study aims to explore the antibacterial effect of halicin and microbial susceptibility using the zone of inhibition and the minimum inhibition concentration (MIC) values while assessing the stability of stored halicin over a period of time with cost-effective and straightforward methods.
Using AI, scientists find a drug that could combat drug-resistant ...
May 25, 2023 · Using an artificial intelligence algorithm, researchers at MIT and McMaster University have identified a new antibiotic that can kill a type of bacteria (Acinetobacter baumannii, pink) that is responsible for many drug-resistant infections.
A Deep Learning Approach to Antibiotic Discovery - Cell Press
A trained deep neural network predicts antibiotic activity in molecules that are structurally different from known antibiotics, among which Halicin exhibits efficacy against broad-spectrum bacterial infections in mice.
AI-Discovered Antibiotic 'Halicin' Fights Resistant Bacteria
Nov 6, 2024 · Halicin is discovered to have a potential of killing bacteria that are resistant to antibiotics. This is a major breakthrough in health research since bacteria resistance to...
Halicin: AI-Powered Revolution in Antibiotic Discovery
AI-Powered Discovery: Halicin was identified using AI to screen over 100 million compounds, accelerating antibiotic discovery. Unique Mechanism: Halicin disrupts bacteria's electrochemical gradient, leading to cell death, unlike traditional antibiotics.
Artificial intelligence yields new antibiotic | Broad Institute
Feb 20, 2020 · The strain of A. baumannii that they used is resistant to all known antibiotics, but application of a halicin-containing ointment completely cleared the infections within 24 hours. Preliminary studies suggest that halicin kills bacteria by disrupting their ability to maintain an electrochemical gradient across their cell membranes.
Using AI, MIT researchers identify a new class of antibiotic …
Dec 20, 2023 · An antibiotic candidate that Collins’ lab discovered in 2020, halicin, appears to work by a similar mechanism but is specific to Gram-negative bacteria (bacteria with thin cell walls). MRSA is a Gram-positive bacterium, with thicker cell walls.