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7:27
jove.com
Video: A Simple Protocol for Platelet-mediated Clumping of Plasmodium falciparum-infected Erythrocytes in a Resource Poor Setting
18.7K Views. Malawi-Liverpool-Wellcome Trust Clinical Research Programme. This method investigates the platelet-mediated clumping phenotype of Plasmodium falciparum-infected erythrocytes (pRBC) in clinical isolates. This is performed by isolating and co-incubating platelet-rich plasma and a suspension of pRBC.
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🍁 Platelet Clumping ( Pre Analytical : Clot or Partial Clot) 🍁 🍁 Pre-Analytical Cause: Collected Specimen in EDTA Tube 🔸 Failure to mix the blood immediately after collection. 🔸 Inadequate inversion (fewer than 8 times), leading to incomplete mixing of blood and anticoagulant → resulting in partial clot formation. 🍁 Effects🍁: 🔸 Causes Platelet Clumping. 🔸 Leads to falsely low platelet counts. 🔸 May result in erroneous CBC reports. 🍁 Recommendation🍁: After collecting blood into the ED
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